hokC:Gene Product(s): Difference between revisions

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!{{table heading style}} |Standard name
!align=left {{table heading style}} |Standard name
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HokC product
HokC  
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!{{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
|
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toxic membrane protein, small product<ref name='LIB:Riley_2006'/>, B4412 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Gef product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HokC product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''toxic membrane protein, small<ref name='LIB:Riley_2006'/>, B4412<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Gef<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HokC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0018, gef, JW5879, b4412''
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!{{table heading style}} |Product description
!align=left {{table heading style}} |Product description
|
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HokC, Gef toxin; interferes with membrane function when in excess<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
HokC, Gef toxin; interferes with membrane function when in excess<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  


Component of ; [[:Category:Complex:Gef dimer|Gef dimer]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
Component of [[:Category:Complex:Gef dimer|Gef dimer]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


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!{{table heading style}} |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
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===Notes===
===Notes===
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<big>'''Gene Ontology'''</big><br />{{Product_GO_help}}<!--box uid=421aa90e079fa326b6494f812ad13e79.19433.W46aa156ed40ed-->
<big>'''Gene Ontology'''</big><br /><!--box uid=421aa90e079fa326b6494f812ad13e79.19433.W46aa156ed40ed-->
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!Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
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!Partner Type!!Partner!!Notes
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Protein
Protein
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Subunits of [[:Category:Complex:Gef dimer|Gef dimer]]  
Subunits of [[:Category:Complex:Gef dimer|Gef dimer]]  
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could be indirect   
could be indirect  
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===Notes===
===Notes===
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!Compartment!!Description!!Evidence!!Notes
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plasma membrane
plasma membrane
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From EcoCyc<ref name='LIB:EcoCyc11.1'/>   
From EcoCyc<ref name='LIB:EcoCyc11.1'/>  
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!align=left {{table heading style}} |Name
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!{{table heading style}} |Sequence
!align=left {{table heading style}} |Sequence
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[http://biocyc.org/ECOLI/sequence-aa?object=MONOMER0-1564 at EcoCyc]  
[http://biocyc.org/ECOLI/sequence-aa?object=MONOMER0-1564 at EcoCyc]  
<pre>MKQHKAMIVA LIVICITAVV AALVTRKDLC EVHIRTGQTE VAVFTAYESE</pre>  
<pre>MKQHKAMIVA LIVICITAVV AALVTRKDLC EVHIRTGQTE VAVFTAYESE</pre>  
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!{{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Length
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5.5 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
50
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!{{table heading style}} |pI
!align=left {{table heading style}} |Mol. Wt
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5.5 kDa
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!{{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |pI
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1490 - 1740 (calc based on 1 Y, 0 W, and 2 C residues)  
7.3 (calculated)
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!align=left {{table heading style}} |Extinction coefficient
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1,490 - 1,740 (calc based on 1 Y, 0 W, and 2 C residues)
 
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==Domains/Motifs/Modification Sites==
 
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<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span><table>
<tr align="left" valign="top">
<td><!--box uid=421aa90e079fa326b6494f812ad13e79.19433.X46aa15721dec8-->
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!Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
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Domain
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2..50
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[http://pfam.janelia.org/family/PF01848 PF01848  Hok/gef family]
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PMID:19920124
 
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<td>
<!-- motifs column 2-->
<motif_map/>
</td>
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</table>


<span id="Structure"></span><big>'''Structure'''</big>
<table><tr valign='top'><td>
<span id='Structure'></span><big>'''Structure'''</big><br />
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|-
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!align=left {{table heading style}} |Structures
!align=left {{table heading style}} |Structures
||
||
<beststructure>hokC
<beststructure>
562</beststructure>
gene=hokC
 
taxon=562,83333
</beststructure>
|-
|-
!align=left {{table heading style}} |Models
!align=left {{table heading style}} |Models
||
||
View models at:
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=hokC&sub=keywordSearc EcoliPredict]
* [http://www.proteinmodelportal.org/query/uniprot/P0ACG4 Protein Model Portal]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=hokC&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0ACG4 PSI-PRED (P0ACG4)]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0ACG4 Genomes TO Protein (P0ACG4)] (GTOP)
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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<!--Structure_notes--></protect>
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==== Structure figures ====
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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===Notes===
===Notes===


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===Notes===
===Notes===
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!Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-
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[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
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[http://www.ncbi.nlm.nih.gov/protein/49175991 GI:49175991]
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Escherichia coli str. K-12 substr. MG1655
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[[ASAP]]
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ASAP:ABE-0047278
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
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[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
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[http://www.uniprot.org/uniprot/P0ACG4 UniProtKB/Swiss-Prot:P0ACG4]
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Escherichia coli str. K-12 substr. MG1655
|-
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[[EcoCyc]]
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EcoCyc:G0-9563
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-  
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[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
[[EcoGene]]
|
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[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=MONOMER0-1564 EcoCyc:MONOMER0-1564] 
EcoGene:EG10373
|
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
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[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
|
[[uniprot:P0ACG4|UniProt:P0ACG4]] 
[http://www.ncbi.nlm.nih.gov/gene?term=2847744 GeneID:2847744]
|
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Escherichia coli str. K-12 substr. MG1655
|-
|-  
|
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
|
[http://www.sanger.ac.uk/family?acc=PF01848 PFAM:PF01848]
[http://www.ncbi.nlm.nig.gov/protein/Array GeneID:2847744]
|
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Escherichia coli str. K-12 substr. MG1655
|-
|-  
|
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[RegulonDB]]
|
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=YP_025292 RefSeq:YP_025292] 
RegulonDB:ECK120002652
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
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[http://BioCyc.org/ECOO157/ ECOO157CYC] ([[ECOO157CYC|EcoliWiki Page]])
[[EchoBASE]]
|
|
[http://BioCyc.org/ECOO157/new-image?object=GEF-MONOMER ECOO157CYC:GEF-MONOMER] 
EchoBASE:EB0368
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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===Notes===
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===Categories===
===Categories===
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[[Category:Proteins]]
[[Category:Proteins]]
[[Category:Complex:Gef dimer]][[Category:Location:plasma membrane]]
[[Category:Complex:Gef dimer]][[Category:Location:plasma membrane]]
[[Category:Pfam:PF01848_!_Hok/gef family]]

Latest revision as of 20:19, 17 February 2015

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

HokC

Synonyms

toxic membrane protein, small[1], B4412[2][1], Gef[2][1], HokC[2][1] , ECK0018, gef, JW5879, b4412

Product description

HokC, Gef toxin; interferes with membrane function when in excess[2][3];

Component of Gef dimer[2][3]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of Gef dimer

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

From EcoCyc[3]


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKQHKAMIVA LIVICITAVV AALVTRKDLC EVHIRTGQTE VAVFTAYESE
Length

50

Mol. Wt

5.5 kDa

pI

7.3 (calculated)

Extinction coefficient

1,490 - 1,740 (calc based on 1 Y, 0 W, and 2 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

2..50

PF01848 Hok/gef family

PMID:19920124[4]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hokC taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:49175991

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0047278

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ACG4

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G0-9563

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10373

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:2847744

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:2847744

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002652

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0368

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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