acrA:Quickview: Difference between revisions

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{|   id="O49aedf28a6e68" class=" tableEdit New_Quickview_Table"


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!align=left {{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[acrA:Gene|''acrA]]'' (synonyms: ''ECK0457, b0463, JW0452, Mb, lir, mbl, mtcA, sipB, nbsA'')<ref name='LIB:Riley_2006'/>
''acrA''
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!align=left {{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[acrA:Gene_Product(s)|AcrA product]]<ref name='LIB:Riley_2006'/>: multidrug efflux system product, B0463 product, SipB product, Mbl product, Lir product, NbsA product, MtcA product, acridine efflux pump product
''ECK0457, b0463, JW0452, Mb, lir, mbl, mtcA, sipB, nbsA''<ref name='LIB:Riley_2006'/>
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!align=left {{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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AcrA Membrane Fusion Protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
AcrA Membrane Fusion Protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:AcrAB-TolC Multidrug Efflux System|AcrAB-TolC Multidrug Efflux System]]<ref name='LIB:EcoCyc10.6'/>
Component of [[:Category:Complex:AcrAB-TolC Multidrug Efflux System|AcrAB-TolC Multidrug Efflux System]]<ref name='LIB:EcoCyc10.6'/>; [[:Category:Complex:AcrAB-TolC Multidrug Efflux System|AcrAB-TolC Multidrug Efflux Transport System]]<ref name='LIB:EcoCyc11.1'/>


AcrAB-TolC multidrug efflux pump; additionally dye, detergent, solvent resistance; membrane-fusion lipoprotein<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Product Synonyms(s)
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''multidrug efflux system<ref name='LIB:Riley_2006'/>, B0463<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SipB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Mbl<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Lir<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NbsA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MtcA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AcrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, acridine efflux pump<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0457, JW0452, lir, Mb, mbl, mtcA, sipB, b0463''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:acrAB|acrAB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:acrAB|acrAB]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=acrA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11703]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120001646&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=acrA&loc=MG1655%3A484843..483650,W3110%3A484843..483650,DH10B%3A424174..422981,REL606%3A457686..456493,BW2952%3A386409..387602]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=386409&end=387602&gene=acrA&aa=mnknrgftplavvlmlsgslaltgcddkqaqqggqqmpavgvvtvkteplqittelpgrtsayriaevrpqvsgiilkrnfkegsdieagvslyqidpatyqatydsakgdlakaqaaaniaqltvnryqkllgtqyiskqeydqaladaqqanaavtaakaavetarinlaytkvtspisgrigksnvtegalvqngqatalatvqqldpiyvdvtqssndflrlkqelangtlkqengkakvslitsdgikfpqdgtlefsdvtvdqttgsitlraifpnpdhtllpgmfvrarleeglnpnailvpqqgvtrtprgdatvlvvgaddkvetrpivasqaigdkwlvteglkagdrvvisglqkvrpgvqvkaqevtadnnqqaasgaqpeqsks]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=acrA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=acrA]]&nbsp;&nbsp;


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Latest revision as of 21:53, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

acrA

Gene Synonym(s)

ECK0457, b0463, JW0452, Mb, lir, mbl, mtcA, sipB, nbsA[1]

Product Desc.

AcrA Membrane Fusion Protein[2][3];

Component of AcrAB-TolC Multidrug Efflux System[2]; AcrAB-TolC Multidrug Efflux Transport System[3]

AcrAB-TolC multidrug efflux pump; additionally dye, detergent, solvent resistance; membrane-fusion lipoprotein[4]

Product Synonyms(s)

multidrug efflux system[1], B0463[2][1], SipB[2][1], Mbl[2][1], Lir[2][1], NbsA[2][1], MtcA[2][1], AcrA[2][1], acridine efflux pump[2][1] , ECK0457, JW0452, lir, Mb, mbl, mtcA, sipB, b0463

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): acrAB[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


acrA was first identified as an acridine sensitive mutation. acrA is a mutational suppressor of topA deletion inviability in low osmolarity medium. AcrA is attached to the inner membrane. acrA is an acrE paralog. AcrA is trimeric. Mar regulon. First 24 aa are a type II signal peptide.[4]



References

[back to top]


  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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