rppH:Quickview: Difference between revisions

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{{Tab On|Quickview|nudH}}{{Tab|Gene|nudH}}{{Tab|Gene Product(s)|nudH}}{{Tab|Expression|nudH}}{{Tab|Evolution|nudH}}{{Tab|On One Page|nudH}}{{TabsBottom}}
{{Tab On|Quickview|rppH}}{{Tab|Gene|rppH}}{{Tab|Gene Product(s)|rppH}}{{Tab|Expression|rppH}}{{Tab|Evolution|rppH}}{{Tab|On One Page|rppH}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[nudH:Gene|''nudH]]'' (synonyms: ''ECK2826, b2830, JW2798, ydgP, ygdP'')<ref name='LIB:Riley_2006'/>
''rppH <ref name=PMID:18202662/>''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[nudH:Gene_Product(s)|NudH product]]<ref name='LIB:Riley_2006'/>: nucleotide hydrolase product, B2830 product, YgdP product
''nudH, ECK2826, b2830, JW2798, ydgP, ygdP''<ref name='LIB:Riley_2006'/>, ygdP''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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putative  invasion protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
RNA pyrophosphohydrolase (removes the 5'-pyrophosphate from mRNAs and initiates degradation by the 5'-end dependent pathway)<ref name='PMID:18202662'/>; putative  invasion protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
 
RNA pyrophosphohydrolase, destabilizes primary transcripts<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''NudH,nucleotide hydrolase<ref name='LIB:Riley_2006'/>, B2830<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, NudH<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YgdP<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ECK2826, JW2798, nudH, ygdP, b2830''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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Many mRNAs have an increased half-life. <ref name='PMID:18202662'/>
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:ptsP|ptsP]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:ptsP|ptsP]]<ref name='LIB:EcoCyc10.6'/>
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=rppH&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=G7459]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120004022&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=rppH&loc=MG1655%3A2966999..2966469,W3110%3A2967633..2967103,BW2952%3A2853617..2854147]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2853617&end=2854147&gene=rppH&aa=midddgyrpnvgivicnrqgqvmwarrfgqhswqfpqgginpgesaeqamyrelfeevglsrkdvrilastrnwlryklpkrlvrwdtkpvcigqkqkwfllqlvsgdaeinmqtsstpefdgwrwvsywypvrqvvsfkrdvyrrvmkefasvvmslqentpkpqnasayrrkrg]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=rppH+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=rppH]]&nbsp;&nbsp;
 
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===Notes===
===Notes===
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Nudix hydrolase. RppH removes 5' triphosphate from primary transcripts, enhancing RNase E activity (Deana, 2008). Required for invasion of cultured mammalian cells by both E. coli K1 and S. typhimurium.  NudH also hydrolyzes Ap5A and Ap4A. Ribosome-associated protein (Jiang, 2007).<ref name='LIB:EcoGene'/>




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==References==
==References==
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Latest revision as of 21:46, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

rppH [1]

Gene Synonym(s)

nudH, ECK2826, b2830, JW2798, ydgP, ygdP[2], ygdP

Product Desc.

RNA pyrophosphohydrolase (removes the 5'-pyrophosphate from mRNAs and initiates degradation by the 5'-end dependent pathway)[1]; putative invasion protein[3][4] RNA pyrophosphohydrolase, destabilizes primary transcripts[5]

Product Synonyms(s)

NudH,nucleotide hydrolase[2], B2830[3][2], NudH[3][2], YgdP[3][2], ECK2826, JW2798, nudH, ygdP, b2830

Function from GO

<GO_nr />

Knock-Out Phenotype

Many mRNAs have an increased half-life. [1]

Regulation/Expression

transcription unit(s): ptsP[3]

Regulation/Activity
Quick Links



        

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See Help:Quickview for help with entering information in the Quickview table.

Notes

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Nudix hydrolase. RppH removes 5' triphosphate from primary transcripts, enhancing RNase E activity (Deana, 2008). Required for invasion of cultured mammalian cells by both E. coli K1 and S. typhimurium. NudH also hydrolyzes Ap5A and Ap4A. Ribosome-associated protein (Jiang, 2007).[5]



References

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  1. ↑ 1.0 1.1 1.2 Deana, A et al. (2008) The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal. Nature 451 355-8 PubMed
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ 5.0 5.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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