thyA:Quickview: Difference between revisions

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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[thyA:Gene|''thyA]]'' (synonyms: ''ECK2823, b2827, JW2795'')<ref name='LIB:Riley_2006'/>
''thyA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[thyA:Gene_Product(s)|ThyA product]]<ref name='LIB:Riley_2006'/>: thymidylate synthetase product, B2827 product, 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase product
''ECK2823, b2827, JW2795''<ref name='LIB:Riley_2006'/>, JW2795''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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thymidylate synthase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
thymidylate synthase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:thymidylate synthase|thymidylate synthase]]<ref name='LIB:EcoCyc10.6'/>
Component of [[:Category:Complex:thymidylate synthase|thymidylate synthase]]<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Thymidylate synthase; aminopterin, trimethoprim resistance; homodimer<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''thymidylate synthetase<ref name='LIB:Riley_2006'/>, B2827<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ThyA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK2823, JW2795, b2827''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:lgt-thyA|lgt-thyA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:lgt-thyA|lgt-thyA]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=thyA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11002]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000991&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=thyA&loc=MG1655%3A2963177..2962383,W3110%3A2963811..2963017,REL606%3A2859775..2858981,DH10B%3A3057047..3056253,BW2952%3A2849531..2850325]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2849531&end=2850325&gene=thyA&aa=mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttkrchlrsiihellwflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlkndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfniasyallvhmmaqqcdlevgdfvwtggdthlysnhmdqthlqlsreprplpkliikrkpesifdyrfedfeiegydphpgikapvai]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=thyA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=thyA]]&nbsp;&nbsp;
 
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===Notes===
===Notes===
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Thymidylate synthase (TS) catalytic mechanism order: TS + dUMP --> TS x dUMP + (6R)-5,10-CH2-H4folate --> TS x dUMP x (6R)-5,10-CH2H4folate --> TS x dTMP x H2folate --> TS x dTMP --> TS.<ref name='LIB:EcoGene'/>




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==References==
==References==
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<references/>
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Latest revision as of 21:45, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

thyA

Gene Synonym(s)

ECK2823, b2827, JW2795[1], JW2795

Product Desc.

thymidylate synthase[2][3];

Component of thymidylate synthase[2][3]

Thymidylate synthase; aminopterin, trimethoprim resistance; homodimer[4]

Product Synonyms(s)

thymidylate synthetase[1], B2827[2][1], ThyA[2][1], 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase[2][1] , ECK2823, JW2795, b2827

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): lgt-thyA[2]

Regulation/Activity
Quick Links



        

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Notes

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Thymidylate synthase (TS) catalytic mechanism order: TS + dUMP --> TS x dUMP + (6R)-5,10-CH2-H4folate --> TS x dUMP x (6R)-5,10-CH2H4folate --> TS x dTMP x H2folate --> TS x dTMP --> TS.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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