trkA:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
<protect>
| Standard Name |
trkA |
|---|---|
| Gene Synonym(s) |
ECK3276, b3290, JW3251[1], JW3251, sapG |
| Product Desc. |
NAD-binding component of TrK potassium transporter[2][3] Major constitutive K+ uptake permeases TrkAG and TrkAH; high-rate, low-affinity transport; peripheral membrane protein bound to inner membrane protein TrkG or TrkH to form active permease; binds NAD+ and NADH[4] |
| Product Synonyms(s) |
NAD-binding component of TrK potassium transporter[1], B3290[2][1], TrkA[2][1] , ECK3276, JW3251, sapG, b3290 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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Notes
Although normally required for Trk activity, overproduction of TrkG or TrkH alone increases K+ transport in a trkA mutant strain (Buurman, 2004). Has two complete TrkA(RCK) domains. SapD(TrkE) is required for TrkAH activity and stimulates TrkAG transport rate (Bossemeyer, 1989; Dosch, 1991; Harms, 2001). Trk-mediated transport is driven by proton motive force, but requires a high ATP concentration for maximal activity, presumably because ATP-binding is needed to activate SapD (Harms, 2001). Anaerobically, TrkAH is proposed to form a membrane supercomplex with the F0F1 ATPase and formate-hydrogen lyase (HycB-HycE-FdhF) responsible for hydrogen gas production and 2H+/K+ exchange; thiol groups are required for this activity (Trchounian, 2000).[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
