thiH:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
<protect>
| Standard Name |
thiH |
|---|---|
| Gene Synonym(s) |
ECK3981, b3990, JW3953, thiA, thiB[1], thiB |
| Product Desc. |
Component of thiamin biosynthesis ThiGH complex[3] Tyrosine lyase, involved in thiamin-thiazole moiety synthesis; complexes with ThiG; [4Fe-4S] cluster[4] |
| Product Synonyms(s) |
thiamin biosynthesis ThiGH complex subunit[1], B3990[2][1], ThiB[2][1], ThiH[2][1] , ECK3981, JW3953, thiB, b3990 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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| edit table |
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Notes
Anaerobically, glycine probably cannot be oxidized to form the probable thiamine biosynthetic intermediate dehydroglycine, so it is derived from tyrosine by the action of the tyrosine lyase ThiH; the products of the in vitro ThiH reaction are para-cresol and hydroglycine (Kriek, 2007). In E. coli B, para-cresol is probably converted to 4-hydroxy-benzoyl alcohol in vivo by an oxidase that is missing from K strains (Kriek, 2007), and thus 4-hydroxy-benzoyl alcohol is probably not the primary tyrosine cleavage product as previously suggested (White, 1979). Radical SAM superfamily.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
