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References Suggestions


Standard Name


Gene Synonym(s)

ECK2778, b2784, JW2755, RC[1], RC

Product Desc.


ATP:GTP 3'-pyrophosphotransferase, ppGpp synthetase I; required for ppGpp synthesis during stringent response to amino acid starvation; self regulated[4]

Product Synonyms(s)

(p)ppGpp synthetase I/GTP pyrophosphokinase[1], B2784[2][1], RelA[2][1], ppGpp synthase I[2][1] , ECK2778, JW2755, RC, b2784

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): relA-mazEF[2][3], relA-chpRA, chpA

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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RelA has two physically and functionally distinct domains, the N-terminal domain, amino acids 1 to 455, is responsible for (p)ppGpp synthesis, and the C-terminal domain, amino acids 456 to 744, is responsible for self regulation.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.