minD:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
<protect>
| Standard Name |
minD |
|---|---|
| Gene Synonym(s) |
ECK1163, b1175, JW1164, minB[1], minB |
| Product Desc. |
membrane ATPase of the MinC-MinD-MinE system that regulates septum placement[2][3] Inhibition of FtsZ ring polymerization; membrane ATPase that activates MinC; forms membrane-associated coiled arrays on the cytoplasmic face of the inner membrane, more concentrated at the poles[4] |
| Product Synonyms(s) |
membrane ATPase of the MinC-MinD-MinE system[1], B1175[2][1], MinB[2][1], MinD[2][1] , ECK1163, JW1164, minB, b1175 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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| edit table |
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Notes
The membrane localization of MinD is mediated by an 8-12 residue C-terminal motif, the membrane targeting sequence (MTS), mutations in this region prevent membrane localization, but not MinC binding. MinD contains switch I and II regions (regions that undergo nucleotide-dependent conformational changes responsible for interactions with their partners) involved in MinC interactions. MinCD oscillates (migrates) between coating one half of the cell's membrane (minE ring to pole) to coating the other half every 40 secs, and this may help to identify the cell center. Overexpression causes filamentous biofilm formation.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
