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References Suggestions


Standard Name


Gene Synonym(s)

ECK4035, b4043, JW4003, exrA, tsl, umuA[1], spr, umuA

Product Desc.


Component of LexA transcriptional repressor[2][3]

Global regulator (repressor) for SOS regulon; dimeric[4]

Product Synonyms(s)

DNA-binding transcriptional repressor of SOS regulon[1], B4043[2][1], Tsl[2][1], UmuA[2][1], ExrA[2][1], LexA[2][1] , ECK4035, exrA, JW4003, spr, tsl, umuA, b4043

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): lexA-dinF[2], OP00046, lexA

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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LexA autocleavage, stimulated by RecA, of the first 84 aa of LexA removes the DNA binding region and is required to activate the SOS response. LexA recognition site: CTGTATATATATACAG.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.