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References Suggestions


Standard Name


Gene Synonym(s)

ECK2567, b2569, JW2553[1], JW2553

Product Desc.

GTP-binding membrane protein[2]; elongation factor 4[3]

Back-translocating Elongation Factor EF4, GTPase; required for efficient and accurate protein synthesis[4]

Product Synonyms(s)

GTP-binding membrane protein[1], B2569[2][1], LepA[2][1], EF4[3][1] , ECK2567, JW2553, b2569

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): lepAB[2]

Quick Links

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Although EF4 improves translational accuracy, it can not reverse paromomycin-induced errors (Qin, 2006). EF4 is a widely conserved protein, the first four domains are related to EF-G domains I, II, III, and V (Qin, 2006). EF4 overexpression is toxic (Qin 2006). EF4 (LepA) is in the lepAB operon but has no known role in signal peptidase I (LepB) activity.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.