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References Suggestions


Standard Name


Gene Synonym(s)

ECK4137, b4143, JW4103, groEL, mopB, groE, hdh, mopA, tabB[1][2]

Product Desc.

GroEL, chaperone Hsp60, peptide-dependent ATPase, heat shock protein[2][3];

Component of GroEL-GroES Chaperonin-CPLX[3]

Chaperonin Cpn60; phage morphogenesis; GroESL large subunit GroEL, weak ATPase; binds Ap4A[4]

Product Synonyms(s)

Cpn60 chaperonin GroEL, large subunit of GroESL[1], B4143[2][1], Hdh[2][1], TabB[2][1], GroL[2][1], MopA[2][1], GroEL[2][1] , ECK4137, groEL, JW4103, mopA, b4143

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): groS[2], groS, groES

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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groL is an essential gene. GroEL binds and regulates rpoH. Cells deficient in GroEL and GroES lyse due to inability to produce cell wall as a result of the reduced level of DapA, the first enzyme in the DAP synthesis pathway. Growth below 8C is impaired due to GroESL inactivation and can be rescued by transgenic Oleispira antarctica Cpn10/60. Overproduction of GroESL can supress tig/dnaK synthetic lethality at 30 degrees C.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.