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References Suggestions


Standard Name


Gene Synonym(s)

ECK0014, b0014, JW0013, grpF, seg, lop, groPAB, groPC, groPF, grpC, dnaL, groP, groPA[1][2]

Product Desc.

chaperone Hsp70; DNA biosynthesis; autoregulated heat shock proteins[2][3];

Component of DnaJ/DnaK/GrpE[2][3]

Hsp70 molecular chaperone, heat-inducible[4]

Product Synonyms(s)

chaperone Hsp70, co-chaperone with DnaJ[1], B0014[2][1], GrpC[2][1], GrpF[2][1], Seg[2][1], GroP[2][1], DnaL[2][1], DnaK[2][1] , ECK0014, groPAB, groPC, groPF, grpC, grpF, JW0013, seg, b0014

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): dnaKJ[2]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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ATP-regulated binding and release of polypeptide substrates. Binds Zn(II). DnaJ is co-chaperone. Role in the initiation of DNA replication. DnaK has secondary amide peptide bond cis-trans isomerase (APIase) activity. A dnaK mutant is inviable above 42C, or below 8C (as enabled by transgenic Oleispira antarctica Cpn10/60). Delta tig delta dnaK mutants are synthetic lethal at 30 degrees C, however, no lethal effects are observed at 23 degrees C; overproduction of GroEL/GroES at 30 degrees C supresses synthetic lethality. dnaK, hscA, hscC and yegD are paralogs. HT_Cmplx22_Cyt: DnaK+GrpE+GyrA+RpsA. HT_Cmplx30_Mem: ClpB+DnaK+InfB+RpsA. After four hours of Zn(II) stress, protein levels increased (Easton, 2006).[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.