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References Suggestions


Standard Name


Gene Synonym(s)

ECK3992, b4000, JW3964, G119, hydL[1][2]

Product Desc.

DNA-binding protein HU-α (HU-2)[2]; Transcriptional dual regulator HU-α (HU-2)[3];

Component of HU Transcriptional dual regulator[3]

Histone-like protein HU-alpha, HU-2[4]

Product Synonyms(s)

HU, DNA-binding transcriptional regulator, alpha subunit[1], B4000[2][1], HydL[2][1], HupA[2][1] , ECK3992, JW3964, b4000

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): hupA[2]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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HU concentration in the cell determines the mechanical effect; flexible bends responsible for compaction occur at concentrations <100nM, while increased concentrations result in the formation of a rigid nucleoprotein filament and no significant concentration. Mutant HU alters structure and function of the chromosome. HT_Cmplx32_Mem: CspC+Hns+HupA.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.