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References Suggestions


Standard Name


Gene Synonym(s)

ECK2823, b2827, JW2795[1], JW2795

Product Desc.

thymidylate synthase[2][3];

Component of thymidylate synthase[2][3]

Thymidylate synthase; aminopterin, trimethoprim resistance; homodimer[4]

Product Synonyms(s)

thymidylate synthetase[1], B2827[2][1], ThyA[2][1], 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase[2][1] , ECK2823, JW2795, b2827

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): lgt-thyA[2]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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Thymidylate synthase (TS) catalytic mechanism order: TS + dUMP --> TS x dUMP + (6R)-5,10-CH2-H4folate --> TS x dUMP x (6R)-5,10-CH2H4folate --> TS x dTMP x H2folate --> TS x dTMP --> TS.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.