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References Suggestions


Standard Name


Gene Synonym(s)

ECK2566, b2568, JW2552, lep[1], lep

Product Desc.

leader peptidase (signal peptidase I)[2][3]

Signal peptidase I; SPI; responsible for type I signal cleavages of periplasmic, OM, some IM, and extracellular proteins[4]

Product Synonyms(s)

leader peptidase (signal peptidase I)[1], B2568[2][1], Lep[2][1], LepB[2][1], LP1[2][1] , ECK2566, JW2552, lep, b2568

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): lepAB[2]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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LepB has a blocked N-terminus. False positive lipoprotein prediction, shown to have no signal peptide. Targetted by SRP/FtsY to Sec/YidC for membrane insertion.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.