ruvA:Quickview

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Standard Name

ruvA

Gene Synonym(s)

ECK1862, b1861, JW1850[1], JW1850

Product Desc.

branch migration of Holliday structures; repair[2][3];

Component of resolvasome[2][3]

Holliday junction recognition factor, recruits RuvB; works in conjunction with RuvB helicase to drive branch migration during recombination[4]

Product Synonyms(s)

component of RuvABC resolvasome, regulatory subunit[1], B1861[2][1], RuvA[2][1] , ECK1862, JW1850, b1861

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ruvAB[2]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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Binds Holliday junction as two tetramers (an octamer) and each tetrameric half recruits one RuvB hexameric helicase. RuvAB may also directly convert replication forks into Holliday junctions. Required for replication forks reversal in certain replication mutants. LexA regulon. RuvA may be a sliding collar that protects Holliday junctions from unwinding while promoting branch migration[4]



References

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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.