Category:Complex:resolvasome

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Description (originally from EcoCyc[1][2]) resolvasome

Comments (originally from EcoCyc[1][2]) RuvABC is an enzymatic complex which functions in recombination pathways to by binding to recombinational junctions and catalyzing strand cleavage and branch migration.

DNA damage can occur due to a variety of environmental assaults including UV irradiation and chemical agents. Escherichia coli has a number of complex enzymatic pathways for the repair of DNA damage. Most DNA damage involves lesions to one strand of DNA, but in some cases damage can occur to both strands. Repair of double strand breaks (DSBs) cannot be repaired via excision repair pathways because by their nature they lack an intact strand to be used as a template. Repair of DSBs uses the RecA pathway of homologous recombination with a separate, intact, homologous region of DNA. To complete recombinational repair in Escherichia coli, DNA junctions formed during the RecA filament strand exchange must be resolved and the RecA filament must be removed. There are at least two independent enzymatic systems in E.coli for DNA junction removal: the RecG helicase and the RuvABC resolvasome [3][4][5][4][6][7][3].


References

  1. ↑ 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 Kuzminov, A (1999) Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda. Microbiol. Mol. Biol. Rev. 63 751-813, table of contents PubMed
  4. ↑ 4.0 4.1 Courcelle, J & Hanawalt, PC (2003) RecA-dependent recovery of arrested DNA replication forks. Annu. Rev. Genet. 37 611-46 PubMed
  5. ↑ Parsons, CA et al. (1992) Interaction of Escherichia coli RuvA and RuvB proteins with synthetic Holliday junctions. Proc. Natl. Acad. Sci. U.S.A. 89 5452-6 PubMed
  6. ↑ Shah, R et al. (1994) Activation of RuvC Holliday junction resolvase in vitro. Nucleic Acids Res. 22 2490-7 PubMed
  7. ↑ Shurvinton, CE & Lloyd, RG (1982) Damage to DNA induces expression of the ruv gene of Escherichia coli. Mol. Gen. Genet. 185 352-5 PubMed

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