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References Suggestions


Standard Name


Gene Synonym(s)

sfcA, ECK1473, b1479, JW5238, mae, maeA?[1][2][3]

Product Desc.

MaeA[3]; malate dehydrogenase, NAD-requiring[2];

Component of malic enzyme, NAD-linked[3]; malate dehydrogenase, NAD-requiring[2]

Malic enzyme, NAD-dependent; NAD-ME[4]

Product Synonyms(s)

malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme)[1], B1479[3][1], MaeA[3][1], SfcA[3][1] , ECK1473, JW5238, sfcA, b1479

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): sfcA[3]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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MaeA catalyzes four reactions: I, NAD-dependent L-malate decarboxylation; II, NAD-independent oxalacetate decarboxylation; III, oxalacetate reductase, NAD-dependent; !V, pyruvate reductase, NAD-dependent. Acetyl-CoA and ATP are allosteric inhibitors; aspartate is an allosteric activator. Reaction I proceeds by two steps: dehydrogenation, then decarboxylation.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.