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References Suggestions


Standard Name


Gene Synonym(s)

ECK1246, b1252, JW5195, T1rec, exbA[1], exbA

Product Desc.

TonB protein; energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins[2][3];

Component of TonB energy transducing system[3]; Outer Membrane Ferric Citrate Transport System[3]; Outer Membrane Ferrichrome Transport System[3]; Outer Membrane Ferric Enterobactin Transport System[3]; vitamin B12 outer membrane transport complex[3]; ferric dicitrate uptake system[3]; ferrichrome uptake system[3]; Ferric Enterobactin Transport System[3]; vitamin B12 transport system[3]

Uptake of chelated Fe(2+) and cyanocobalamin; works in conjunction with OM receptors; energy transducer; sensitivity to T1, phi80, and colicins; forms a complex with ExbB and ExbD[4]

Product Synonyms(s)

membrane spanning protein in TonB-ExbB-ExbD complex[1], B1252[2][1], ExbA[2][1], TonB[2][1] , ECK1246, exbA, JW5195, T1rec, b1252

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): tonB[2], OP00228

Quick Links

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Periplasmic TonB is anchored to the cytoplasmic membrane by a signal anchor and interacts with outer membrane proteins, thus TonB spans the periplasmic space. TonB contains 40 proline residues (17%).[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.