dinB:Quickview

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
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Standard Name

dinB

Gene Synonym(s)

ECK0232, b0231, JW0221, dinP[1], dinP

Product Desc.

DNA polymerase IV (Y-family DNA polymerase; translesion DNA synthesis)[2][3]

DNA polymerase IV, capable of translesion synthesis; overexpression enhances mutagenesis; mediates targeted mutagenesis by 4-NQO; intrinsic AP lyase activity[4]

Product Synonyms(s)

DNA polymerase IV[1], B0231[2][1], DinB[2][1], DinP[2][1] , dinP, ECK0232, JW0221, b0231

Function from GO

<GO_nr />

Knock-Out Phenotype

Sensitivity to 4-NQO [5]

Regulation/Expression

transcription unit(s): dinB[2] dinB yafNOP[6]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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Part of dinB-yafNOP operon. LexA regulon. The phenotype of some dinB alleles to reduce spontaneous mutations may be due to polarity effects.[4]



References

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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Jarosz, DF et al. (2006) A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates. Nature 439 225-8 PubMed
  6. Courcelle, J et al. (2001) Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli. Genetics 158 41-64 PubMed