The Comprehensive Antibiotic Resistance Database
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A bioinformatic database of resistance genes, their products and associated phenotypes. |
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Gerry D. Wright, McMaster University Fazmin Nizam, McMaster University Nicholas Waglechner, McMaster University Andrew G. McArthur, AGM Bioinformatics Consulting |
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Contents
About The Comprehensive Antibiotic Resistance Database
The Comprehensive Antibiotic Resistance Database is a bioinformatic database of resistance genes, their products and associated phenotypes hosted by the laboratory of Dr. Gerry Wright, Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Addressing the challenge of antibiotic resistance requires the combined efforts of researchers that span inquiry at the molecular, patient, and population levels. Yet, despite the common objective of finding solutions to drug resistance, practitioners of these research areas do not often integrate their research findings. This reality reflects the disparate investigative tools, timelines and specific project aims of these disciplines. Nevertheless, resistance genes and their products are the common elements that bridge antibiotic resistance research from bench to clinic to population. What is lacking in the field is a comprehensive database of resistance genes that includes molecular, clinical, and surveillance data that can serve to unify research. We have established a UK-Canada consortium of antibiotic resistance researchers from all areas of resistance investigation to establish an Antibiotic Resistance Pipeline. Phase 1 of the project is to establish the consortium and begin the construction of a Comprehensive Antibiotic Resistance Database (CARD). This database will form the foundation of phase 2 projects to be funded by other means that will seek to add new information to the database and draw upon it to seek solutions to antibiotic resistance. The Antibiotic Resistance Pipeline provides an opportunity to unify the sub-fields of antibiotic resistance research to the benefit of clinical practice, fundamental research, and drug development.
Content
At the genome and plasmid level, CARD focuses upon MRSA and Acinetobacter baumannii, plus a handful of examples from a number of other bacterial species. This has been supplmented with an extensive set of reference genes involved antibiotic resistance from a variety of organisms, genomes, and plasmids. CARD's overall emphasis is primarily upon molecular data and development of an Antibiotic Resistance Ontology to guide annotation of resistance mechanisms, determinants, and targets. This reference information is used to power new annotation tools, such as our Resistance Gene Identifier for annotation of whole genomes or genome assemblies.
Using The Comprehensive Antibiotic Resistance Database
Browsing
Searching
Usage examples
Add links to additional pages describing success stories here.
CARD maintains a list of antibiotic resistance related databases.
Technology
CARD is Generic Model Organism Database (GMOD), using the Chado schema and GBrowse2.
Web Services/API
Discussion
References
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External Links
The Comprehensive Antibiotic Resistance Database
