DNA Topology
Contents
About
The E.coli chromosome consists of 4.6Mbps. The closed circular nature of the chromosome leads to a unique topological organization within the nucleoid of the cell. It also leads to topological constraints upon replication and segregation.
Types of Topology
- Supercoiling
The two complimentary strands of DNA are twisted along its length. The number of base pairs per turn varies depending on the form of DNA.
- Precatenanes
- Hemicatenanes
ISBN 0-12-645750-6
Proteins Involved in Topological Maintenance
Experimental Resources
Related GO Terms
References
See Help:References for how to manage references in EcoliWiki.
- ↑ Marians, KJ (1987) DNA gyrase-catalyzed decatenation of multiply linked DNA dimers. J. Biol. Chem. 262 10362-8 PubMed
- ↑ McClendon, AK et al. (2005) Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks. J. Biol. Chem. 280 39337-45 PubMed
