recQ:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
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| Standard Name |
recQ |
|---|---|
| Gene Synonym(s) |
ECK3816, b3822, JW5855[1] |
| Product Desc. |
ATP-dependent DNA helicase[2][3] DNA helicase involved in recombination, replication, repair; ATP-dependent; monomeric[4] |
| Product Synonyms(s) | |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
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Notes
Helicases generally separate duplex nucleic acids into separate strands. RecQ helicase couples the energy of ATP hydrolysis in order to unwind double-stranded DNA and RNA molecules. [5]
Associated syndromes with mutations on the recQ gene include Werner's, Bloom's, and Rothmund-Thomson Syndrome, which are all autosomal recessive disorders. Werner's Syndrome occurs due to a mutation on the WRN gene and causes loss of skin elasticity, osteoporosis, and atherosclerosis in humans. Bloom's occurs on the BLM gene and is associated with immuno-deficiency, male infertility, and predisposition to all types of cancer. Rothmund-Thomson syndrome is due to a mutation on the RECQ4 gene and causes growth deficiency, early graying and hair loss, and increased cancer incidence in humans. [6]
SSB binds to RecQ and stimulates DNA unwinding (Shereda, 2007). LexA regulon.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Killoran, MP & Keck, JL (2006) Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res. 34 4098-105 PubMed
- ↑ Mohaghegh, P & Hickson, ID (2001) DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Hum. Mol. Genet. 10 741-6 PubMed