rseP:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
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| Standard Name |
|---|
| Gene Synonym(s) |
| Product Desc. |
| Product Synonyms(s) |
| Knock-Out Phenotype |
| Regulation/Expression |
| Regulation/Activity |
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Notes
RpoE regulon. RseP activates RpoE and releases membrane-bound RseA-RpoE complexes. Cleavage occurs around RseA membrane domain generating the N-terminal and the soluable product. rseP is an essential gene, but deletion of ompCF or ompCA (or an sRNA rseX clone, which suppresses ompCA translation) allows growth. RseP or some other protease degrades RseA in the released complexes. The RseA periplasmic domain must be first clipped or degraded by DegS before it is a substrate for RseP. RseP is related to the E. faecalis Eep protein involved in bacterial regulated intramembrane proteolysis (RIP). RseP has been topology mapped using protein fusions. RseP is reported to degrade RpoE and RpoH in vitro and to be an negative, not positive, effector of RpoE action in vivo, but the physiological relevance and/or accuracy of this has been strongly challenged.[1]
References