gspB:Quickview
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Notes
GspB is a distant homolog or convergent analog of exeB of A. hydrophila, which is required for protein export , specifically for the export and assembly of secretin (ExeD/GspD) into the outer membrane. GspB has a single predicted N-terminal transmembrane segment (28-50), followed by a predicted periplasmic domain, which may interact with GspA. GspA may interact with GspB. A divergon is a regulon comprised of two adjacent divergent operons or genes. gspB was initially identified as an ORF that might be the 11.3 kDa PinO protein synthesized in the absence of isoleucine in relA stains (Guzman, 1991). But GspB is predicted to be 15.9 kDa and has isoleucine residues and there is no evidence that gspB encodes the PinO peptide or that it binds calcium. No homology to calmodulin or other calcium-binding proteins is predicted. gspB may have been mistaken for pinO due to use of a downstream ATG as start codon, but the 11 kD C-terminal fragment does have an Ile reside in it, making gspB inconsistent with pinO. pioO was the prior gene name assigned to pinO since the gene name pin was already taken.[1]
References