ampG:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
ampG |
|---|---|
| Gene Synonym(s) |
ECK0427, b0433, JW0423[1] |
| Product Desc. |
AmpG muropeptide MFS transporter[2][3] Muropeptide permease, imports GlcNAc-anhMurNAc-peptides; required for cloned Citrobacter freundii AmpR-regulated beta-lactamase induction and murein recycling[4] |
| Product Synonyms(s) | |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
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Notes
Imported muropeptides must contain the disaccharide GlcNAc-anhMurNAc, which is also efficiently transported without attached peptides. Mutants accumulate GlcNAc-anhMurNAc-tripeptide. Transport inhibited by CCCP. 14 TM helices are [predicted, but fusion studies indicate that predicted hydrophobic helices 5, 6, 11, and 12 are in cytoplasmic loops; AmpG probably has 10 TM helices with N-in, C-in topology. AmpG has been studied using cloned Citrobacter freundii ampR and ampC genes, which are normally on the chromosome of C. freundii. This C. freundii ampC is not the same as the E. coli weak constitutive chromosomal ampC beta-lactamase; E. coli has no ampR gene. Major Facilitator Superfamily (MFS).[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.