yafO:Quickview

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Gene Name

yafO (synonyms: ECK0234, b0233, JW0223)[1]

Product(s)

YafO product[1]: predicted toxin of the YafO-YafN toxin-antitoxin system product, B0233 product

Description

conserved protein with a possible role in spontaneous mutagenesis; toxin of a putative toxin-antitoxin pair[2][3]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): yafN[2]

Regulation/Activity


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Notes

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LexA regulon. dinB-yafNOP operon. The phenotype of some dinB alleles to reduce spontaneous mutations may be due to polarity effects on yafO. Overexpression causes filamentous biofilm formation and increased CV staining. Overexpression also reported to inhibit growth (Brown, 2003). YafN may be antitoxin for possible toxin YafO.[4]



References

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  1. ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.