groS:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Gene Name |
groS (synonyms: ECK4136, b4142, JW4102, groES, mopA, groE, hdh, mopB, tabB, tabA)[1][2] |
|---|---|
| Product(s) |
GroS product[1]: Cpn10 chaperonin GroES, small subunit of GroESL product, GroE product, B4142 product, Hdh product, TabA product, GroES product, MopB product |
| Description |
GroES, chaperone binds to Hsp60 in pres. Mg-ATP, suppressing its ATPase activity[2][3] Component of GroEL-GroES Chaperonin-CPLX[3] |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
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Notes
GroS binds and regulates rpoH. Cells deficient in GroES and GroEL lyse due to inability to produce cell walls as a result of the reduced level of DapA, the first enzyme in the DAP synthesis pathway. Growth below 8C is impaired due to GroESL inactivation and can be rescued by transgenic Oleispira antarctica Cpn10/60. Overproduction of GroESL can supress tig/dnaK synthetic lethality at 30 degrees C. Binds TrxA (Kumar, 2004).[4]
References
- ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.