PMID:17962566

Kolodkin-Gal, I, Hazan, R, Gaathon, A, Carmeli, S and Engelberg-Kulka, H (2007) A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli.Science 318:652-5

Abstract

<protect>mazEF is a toxin-antitoxin module located on many bacterial chromosomes, including those of pathogens. Here, we report that Escherichia coli mazEF-mediated cell death is a population phenomenon requiring a quorum-sensing molecule that we call the extracellular death factor (EDF). Structural analysis revealed that EDF is a linear pentapeptide, Asn-Asn-Trp-Asn-Asn. Each of the five amino acids of EDF is important for its activity.

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Online version:10.1126/science.1147248 |} </protect>

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