PMID:17962566
| Citation |
Kolodkin-Gal, I, Hazan, R, Gaathon, A, Carmeli, S and Engelberg-Kulka, H (2007) A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli. Science 318:652-5 |
|---|---|
| Abstract |
mazEF is a toxin-antitoxin module located on many bacterial chromosomes, including those of pathogens. Here, we report that Escherichia coli mazEF-mediated cell death is a population phenomenon requiring a quorum-sensing molecule that we call the extracellular death factor (EDF). Structural analysis revealed that EDF is a linear pentapeptide, Asn-Asn-Trp-Asn-Asn. Each of the five amino acids of EDF is important for its activity. |
| Links |
PubMed Online version:10.1126/science.1147248 |
| Keywords |
Amino Acid Sequence; Apoptosis; Aspartate-Ammonia Ligase/genetics; Aspartate-Ammonia Ligase/metabolism; DNA-Binding Proteins/physiology; Endoribonucleases/physiology; Escherichia coli/cytology; Escherichia coli/growth & development; Escherichia coli/physiology; Escherichia coli Proteins/physiology; Microbial Viability; Oligopeptides/chemistry; Oligopeptides/isolation & purification; Oligopeptides/metabolism; Quorum Sensing |
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