Septation
General Description
Invagination of the inner and outer membranes, as well as the cell wall that occurs to separate daughter cells. There are 4 main steps:
- Selection of the division site
- Recruitment of the septal proteins to the division site and formation of the ring
- Constriction of the membrane and cell wall
- Separation of the 2 daughter cells
Components
FtsZ(Z ring), FtsA, FtsK, FtsN, FtsI, FtsE, FtsX, etc.
In order to ensure the chromosome doesn't get guillotined, TopoIV and the XerCD recombinase are also localized to the septa, via FtsK, but they are not involved directly in the membrane closure.
Function
Regulation
Z ring formation can be inhibited by sulA (recA- dependent SOS response) or by the action of the Min system[2]. SOS gets triggered in response to DNA damage. sulA is one of many genes whose expression gets upregulates upon LexA repressor cleavage[3]. The SulA protein directly binds to monomeric FtsZ and inhibits its polymerization[4].
Cell Biology
Experimental Resources
Comparison with other organisms
Notes
References
See Help:References for how to manage references in EcoliWiki.
- ↑ Geissler, B & Margolin, W (2005) Evidence for functional overlap among multiple bacterial cell division proteins: compensating for the loss of FtsK. Mol. Microbiol. 58 596-612 PubMed
- ↑ Shiomi, D & Margolin, W (2007) The C-terminal domain of MinC inhibits assembly of the Z ring in Escherichia coli. J. Bacteriol. 189 236-43 PubMed
- ↑ Hill, TM et al. (1997) sfi-independent filamentation in Escherichia coli Is lexA dependent and requires DNA damage for induction. J. Bacteriol. 179 1931-9 PubMed
- ↑ Cordell, SC et al. (2003) Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ. Proc. Natl. Acad. Sci. U.S.A. 100 7889-94 PubMed