fis:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
fis |
|---|---|
| Gene Synonym(s) |
ECK3248, b3261, JW3229, nbp[1] |
| Product Desc. |
Fis transcriptional dual regulator[2][3] Transcriptional activator for rRNA operons, bends DNA; interacts with RNAP; nucleoid-associated protein; dimeric[4] |
| Product Synonyms(s) |
global DNA-binding transcriptional dual regulator[1], B3261[2][1], Nbp[2][1], Fis[2][1], site-specific DNA inversion stimulation factor; DNA-binding protein; a trans activator for transcription[2][1] |
| Function from GO |
Molecular Function
|
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links | |
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Notes
fis transcription is supercoiling-dependent. Overexpression causes filamentous biofilm formation. Decreased levels of Fis inhibit open complex formation, inhibiting oriC unwinding by blocking IHF and DnaA low affinity binding sites. Polyamine modulon. Mutations affect chromosomal supercoliing.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.