folK:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Standard Name
!align=left |Standard Name
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''folK''  
''folK''  
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!align=left {{table_heading_style}} |Gene Synonym(s)
!align=left |Gene Synonym(s)
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''ECK0141, b0142, JW0138''<ref name='LIB:Riley_2006'/>
''ECK0141, b0142, JW0138''<ref name='LIB:Riley_2006'/>
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!align=left {{table_heading_style}} |Product Desc.
!align=left |Product Desc.
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H2PTERIDINEPYROPHOSPHOKIN<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
H2PTERIDINEPYROPHOSPHOKIN<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
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6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase; monomeric<ref name='LIB:EcoGene'/>
6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase; monomeric<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
!align=left |Product Synonyms(s)
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2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase<ref name='LIB:Riley_2006'/>, HPPK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, B0142<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FolK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase<ref name='LIB:Riley_2006'/>, HPPK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, B0142<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FolK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:pcnB-folK|pcnB-folK]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:pcnB-folK|pcnB-folK]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left |Regulation/Activity
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Revision as of 01:10, 9 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

folK

Gene Synonym(s)

ECK0141, b0142, JW0138[1]

Product Desc.

H2PTERIDINEPYROPHOSPHOKIN[2][3]

6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase; monomeric[4]

Product Synonyms(s)

2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase[1], HPPK[2][1], B0142[2][1], FolK[2][1]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): pcnB-folK[2]

Regulation/Activity


edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


HPPK active center is formed once both substrates, ATP and HP, are bound and this assembly results in confirmational changes primarily in catalytic loops 1-3; catalytic loop 3 moves in the opposite direction upon binding of the nucleotide. Catalytic loop 3 is involved in ternary complex stabilization and is necessary for catalysis.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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