folK:Quickview

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References Suggestions

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Standard Name

folK

Gene Synonym(s)

ECK0141, b0142, JW0138[1], JW0138

Product Desc.

H2PTERIDINEPYROPHOSPHOKIN[2][3]

6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase; monomeric[4]

Product Synonyms(s)

2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase[1], HPPK[2][1], B0142[2][1], FolK[2][1] , ECK0141, JW0138, b0142

Function from GO

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Knock-Out Phenotype
Regulation/Expression

transcription unit(s): pcnB-folK[2]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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HPPK active center is formed once both substrates, ATP and HP, are bound and this assembly results in confirmational changes primarily in catalytic loops 1-3; catalytic loop 3 moves in the opposite direction upon binding of the nucleotide. Catalytic loop 3 is involved in ternary complex stabilization and is necessary for catalysis.[4]



References

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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.