folK:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Standard Name |
folK |
|---|---|
| Gene Synonym(s) |
ECK0141, b0142, JW0138[1], JW0138 |
| Product Desc. |
H2PTERIDINEPYROPHOSPHOKIN[2][3] 6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase; monomeric[4] |
| Product Synonyms(s) |
2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase[1], HPPK[2][1], B0142[2][1], FolK[2][1] , ECK0141, JW0138, b0142 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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| edit table |
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Notes
HPPK active center is formed once both substrates, ATP and HP, are bound and this assembly results in confirmational changes primarily in catalytic loops 1-3; catalytic loop 3 moves in the opposite direction upon binding of the nucleotide. Catalytic loop 3 is involved in ternary complex stabilization and is necessary for catalysis.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.