Category:Complex:MacAB macrolide efflux transporter complex: Difference between revisions
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==About== | |||
'''Description''' (originally from EcoCyc<ref name='LIB:EcoCyc10.6'/>) MacAB macrolide efflux transporter complex | |||
'''Description''' (originally from EcoCyc<ref name='LIB:EcoCyc11.1'/>) MacAB-TolC Macrolide Efflux Transport System | |||
'''Comments''' (originally from EcoCyc<ref name='LIB:EcoCyc10.6'/>) MacAB, also known as YbjYZ, probably forms a complex with outer membrane protein TolC to confer | |||
macrolide resistance via active drug efflux. The <I>macAB</I> genes form an operon with a single promoter | |||
and sequence analysis suggest that MacA is a peripheral membrane protein of the MFP family and MacB | |||
is a half-type ABC protein with four putative TM segments and an N-terminal nucleotide binding region | |||
with both Walker motifs and a characteristic ABC signature sequence. Expression of <I>macAB</I> in a | |||
drug-sensitive <I>E. coli </I> background strain lacking the multidrug efflux transporter genes <I>acrAB</I> | |||
resulted in an eight-fold increased level of resistance to the macrolide erythromycin <ref name='PMID:11544226'/><ref name='PMID:11529556'/><ref name='PMID:11544226'/><ref name='PMID:11529556'/>. | |||
==References== | |||
<references/> | |||
Revision as of 12:26, 20 July 2007
About
Description (originally from EcoCyc[1]) MacAB macrolide efflux transporter complex
Description (originally from EcoCyc[2]) MacAB-TolC Macrolide Efflux Transport System
Comments (originally from EcoCyc[1]) MacAB, also known as YbjYZ, probably forms a complex with outer membrane protein TolC to confer macrolide resistance via active drug efflux. The macAB genes form an operon with a single promoter and sequence analysis suggest that MacA is a peripheral membrane protein of the MFP family and MacB is a half-type ABC protein with four putative TM segments and an N-terminal nucleotide binding region with both Walker motifs and a characteristic ABC signature sequence. Expression of macAB in a drug-sensitive E. coli background strain lacking the multidrug efflux transporter genes acrAB resulted in an eight-fold increased level of resistance to the macrolide erythromycin [3][4][3][4].
References
- ↑ 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 Kobayashi, N et al. (2001) Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. J. Bacteriol. 183 5639-44 PubMed
- ↑ 4.0 4.1 Yamanaka, N et al. (2001) Engraftment of tonsillar mononuclear cells in human skin/SCID mouse chimera--validation of a novel xenogeneic transplantation model for autoimmune diseases. Microbiol Immunol 45 507-14 PubMed
Pages in category "Complex:MacAB macrolide efflux transporter complex"
The following 2 pages are in this category, out of 2 total.