ybaZ:Quickview: Difference between revisions
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YbaZ is homologous to methylated-DNA--protein-cysteine methyltransferases Ada and Ogt, but lacks the active site cysteine. YbaZ binds O(6)-alkylguanine residues in DNA and blocks alkyltransferase action; YbaZ does not remove methyl groups from O(6)-methylguanine-containing DNA nor does it have glycosylase or endonuclease activity (Margison, 2007). YbaZ preferentially binds DNA with an abasic site, has base-flipping activity, and binds HelD (Chen, 2008).<ref name='LIB:EcoGene'/> | |||
Revision as of 02:53, 3 March 2009
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Gene Name | |
|---|---|
| Product(s) |
YbaZ product[1]: predicted methyltransferase product, B0454 product |
| Description |
putative methyltransferase[2] predicted methyltransferase[3] |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
|
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
YbaZ is homologous to methylated-DNA--protein-cysteine methyltransferases Ada and Ogt, but lacks the active site cysteine. YbaZ binds O(6)-alkylguanine residues in DNA and blocks alkyltransferase action; YbaZ does not remove methyl groups from O(6)-methylguanine-containing DNA nor does it have glycosylase or endonuclease activity (Margison, 2007). YbaZ preferentially binds DNA with an abasic site, has base-flipping activity, and binds HelD (Chen, 2008).[4]
References
- ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.