mrcB:Quickview: Difference between revisions
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MrcB is part of a complex with MltA and MipA. The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Full length MrcB is the alpha isoform. A second in vivo ATG start at codon 46 produces the 799 aa gamma isoform. Murein polymerase is an essential function satisfied by either MrcA or MrcB. Mutants have elevated OM vesiculation (McBroom, 2006). MrcB is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.<ref name='LIB:EcoGene'/> | |||
Revision as of 00:12, 3 March 2009
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Gene Name | |
|---|---|
| Product(s) |
MrcB product[1]: fused glycosyl transferase product, transpeptidase product, B0149 product, PonB product, PbpF product, PBP1B product |
| Description |
Component of penicillin-binding protein 1B[3] |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
|
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
MrcB is part of a complex with MltA and MipA. The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Full length MrcB is the alpha isoform. A second in vivo ATG start at codon 46 produces the 799 aa gamma isoform. Murein polymerase is an essential function satisfied by either MrcA or MrcB. Mutants have elevated OM vesiculation (McBroom, 2006). MrcB is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.[4]
References
- ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.