|
|
| Line 1: |
Line 1: |
| ==About==
| | {{Complex placeholder}} |
| '''Description''' (originally from EcoCyc<ref name='LIB:EcoCyc10.6'/>) MacAB macrolide efflux transporter complex
| |
| | |
| '''Description''' (originally from EcoCyc<ref name='LIB:EcoCyc11.1'/>) MacAB-TolC Macrolide Efflux Transport System
| |
| | |
| '''Comments''' (originally from EcoCyc<ref name='LIB:EcoCyc10.6'/>) MacAB, also known as YbjYZ, probably forms a complex with outer membrane protein TolC to confer
| |
| macrolide resistance via active drug efflux. The <I>macAB</I> genes form an operon with a single promoter
| |
| and sequence analysis suggest that MacA is a peripheral membrane protein of the MFP family and MacB
| |
| is a half-type ABC protein with four putative TM segments and an N-terminal nucleotide binding region
| |
| with both Walker motifs and a characteristic ABC signature sequence. Expression of <I>macAB</I> in a
| |
| drug-sensitive <I>E. coli </I> background strain lacking the multidrug efflux transporter genes <I>acrAB</I>
| |
| resulted in an eight-fold increased level of resistance to the macrolide erythromycin <ref name='PMID:11544226'/><ref name='PMID:11529556'/><ref name='PMID:11544226'/><ref name='PMID:11529556'/>.
| |
| | |
| | |
| ==References==
| |
| <references/>
| |
| [[Category:Complexes]]
| |
| [[Category:E. coli complexes]]
| |
Revision as of 12:06, 2 August 2007
Add information about this complex.
Pages in category "Complex:MacAB macrolide efflux transporter complex"
The following 2 pages are in this category, out of 2 total.