PMID:196328

Citation	Bubbers, JE, Blank, KJ, Freedman, HA and Lilly, F (1977) Mechanisms of the H-2 effect on viral leukemogenesis. Scand. J. Immunol. 6:533-9
Abstract	Evidence has been gathered which supports the notion that two distinct but interacting mechanisms, controlled by loci mapping within the H-2 complex, influence Friend murine leukemia virus (FV) disease. One mechanism, controlled by a gene mapping in or close to H-2D, influences the capacity of the H-2D gene product to form molecular complexes with FV molecules in the plasma membrane of infected cells. Formation of a complex appears to provide a target antigen for syngeneic cytotoxic T-lymphocytes, to cause co-capping of FV and H-2D antigens, to permit the selective inclusion of H-2Db molecules into progeny Friend virions, to influence the long-term maintenance of virus production in vitro and, in conjunction with the second mechanism, to stimulate the generation of cytotoxic T-lymphocytes. This second mechanism is controlled by a gene in the H-2K or H-2I region, and, in the presence of an H-2/FV molecular complex immunogen, influences the generation of H-2 restricted cytotxic T-lymphocytes and the rate of rejection of syngeneic FV-induced tumor cells.
Links	PubMed
Keywords	Animals; Antigen-Antibody Complex; Cell Membrane/immunology; Chromosome Mapping; Cytotoxicity Tests, Immunologic; Histocompatibility Antigens; Leukemia Virus, Murine; Mice; Mice, Inbred Strains; Plasma Cells/immunology; T-Lymphocytes/immunology; Tumor Virus Infections/immunology
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