PMID:196328
| Citation |
Bubbers, JE, Blank, KJ, Freedman, HA and Lilly, F (1977) Mechanisms of the H-2 effect on viral leukemogenesis. Scand. J. Immunol. 6:533-9 |
|---|---|
| Abstract |
Evidence has been gathered which supports the notion that two distinct but interacting mechanisms, controlled by loci mapping within the H-2 complex, influence Friend murine leukemia virus (FV) disease. One mechanism, controlled by a gene mapping in or close to H-2D, influences the capacity of the H-2D gene product to form molecular complexes with FV molecules in the plasma membrane of infected cells. Formation of a complex appears to provide a target antigen for syngeneic cytotoxic T-lymphocytes, to cause co-capping of FV and H-2D antigens, to permit the selective inclusion of H-2Db molecules into progeny Friend virions, to influence the long-term maintenance of virus production in vitro and, in conjunction with the second mechanism, to stimulate the generation of cytotoxic T-lymphocytes. This second mechanism is controlled by a gene in the H-2K or H-2I region, and, in the presence of an H-2/FV molecular complex immunogen, influences the generation of H-2 restricted cytotxic T-lymphocytes and the rate of rejection of syngeneic FV-induced tumor cells. |
| Links | |
| Keywords |
Animals; Antigen-Antibody Complex; Cell Membrane/immunology; Chromosome Mapping; Cytotoxicity Tests, Immunologic; Histocompatibility Antigens; Leukemia Virus, Murine; Mice; Mice, Inbred Strains; Plasma Cells/immunology; T-Lymphocytes/immunology; Tumor Virus Infections/immunology |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
See also
References
See Help:References for how to manage references in EcoliWiki.
