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<span style = 'font-size: large'> '''Kolodkin-Gal, I and Engelberg-Kulka, H''' (2008) The extracellular death factor: physiological and genetic factors influencing its production and response in Escherichia coli.''J. Bacteriol.'' '''190''':3169-75</span> | |||
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|{{TableHeadingColor}} |'''Abstract''' || <protect>Gene pairs specific for a toxin and its antitoxin are called toxin-antitoxin modules and are found on the chromosomes of many bacteria. The most studied of these modules is Escherichia coli mazEF, in which mazF encodes a stable toxin, MazF, and mazE encodes a labile antitoxin, MazE, which prevents the lethal effect of MazF. In a previous report from this laboratory, it was shown that mazEF-mediated cell death is a population phenomenon requiring a quorum-sensing peptide called the extracellular death factor (EDF). EDF is the linear pentapeptide NNWNN (32). Here, we further confirm that EDF is a signal molecule in a mixed population. In addition, we characterize some physiological conditions and genes required for EDF production and response. Furthermore, stress response and the gene specifying MazEF, the Zwf (glucose-6-phosphate dehydrogenase) gene, and the protease ClpXP are critical in EDF production. Significant strain differences in EDF production and response explain variations in the induction of mazEF-mediated cell death.</protect> | |||
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* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18310334 PubMed] | |||
Online version:[http://dx.doi.org/10.1128/JB.01918-07 10.1128/JB.01918-07] | |||
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Revision as of 22:14, 9 August 2011
Kolodkin-Gal, I and Engelberg-Kulka, H (2008) The extracellular death factor: physiological and genetic factors influencing its production and response in Escherichia coli.J. Bacteriol. 190:3169-75
| Abstract | <protect>Gene pairs specific for a toxin and its antitoxin are called toxin-antitoxin modules and are found on the chromosomes of many bacteria. The most studied of these modules is Escherichia coli mazEF, in which mazF encodes a stable toxin, MazF, and mazE encodes a labile antitoxin, MazE, which prevents the lethal effect of MazF. In a previous report from this laboratory, it was shown that mazEF-mediated cell death is a population phenomenon requiring a quorum-sensing peptide called the extracellular death factor (EDF). EDF is the linear pentapeptide NNWNN (32). Here, we further confirm that EDF is a signal molecule in a mixed population. In addition, we characterize some physiological conditions and genes required for EDF production and response. Furthermore, stress response and the gene specifying MazEF, the Zwf (glucose-6-phosphate dehydrogenase) gene, and the protease ClpXP are critical in EDF production. Significant strain differences in EDF production and response explain variations in the induction of mazEF-mediated cell death. |
|- |bgcolor='#CCCCFF' nowrap |Links ||
Online version:10.1128/JB.01918-07 |} </protect>
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