mrcB:Quickview: Difference between revisions
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Revision as of 19:33, 2 February 2010
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
See Help:Quickview for help with entering information in the Quickview table.
| Standard Name |
mrcB |
|---|---|
| Gene Synonym(s) |
ECK0148, b0149, JW0145, pbpF, ponB[1] |
| Product Desc. |
Component of penicillin-binding protein 1B[3] Murein polymerase, PBP1B; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1B; dimeric[4] |
| Product Synonyms(s) |
fused glycosyl transferase[1], transpeptidase[1], B0149[2][1], PonB[2][1], PbpF[2][1], MrcB[2][1], PBP1B[2][1] |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links | |
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
MrcB is part of a complex with MltA and MipA. The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Full length MrcB is the alpha isoform. A second in vivo ATG start at codon 46 produces the 799 aa gamma isoform. Murein polymerase is an essential function satisfied by either MrcA or MrcB. Mutants have elevated OM vesiculation (McBroom, 2006). MrcB is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.