seqA:Quickview: Difference between revisions
Update TableEdit tables. |
update QV table |
||
| Line 27: | Line 27: | ||
|- | |- | ||
!align=left | !align=left {{table_heading_style}} |Standard Name | ||
|| | || | ||
''seqA'' | ''seqA'' | ||
|- | |- | ||
!align=left | !align=left {{table_heading_style}} |Gene Synonym(s) | ||
|| | || | ||
''ECK0675, b0687, JW0674''<ref name='LIB:Riley_2006'/> | ''ECK0675, b0687, JW0674''<ref name='LIB:Riley_2006'/> | ||
|- | |- | ||
!align=left | !align=left {{table_heading_style}} |Product Desc. | ||
|| | || | ||
SeqA, negative modulator of initiation of replication<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/> | SeqA, negative modulator of initiation of replication<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/> | ||
| Line 41: | Line 41: | ||
Sequesters newly replicated hemimethylated oriC origins to prevent re-initiation; binds hemimethylated GATC sequences; SeqA foci required for chromosome segregation; binds and stimulates Topo IV<ref name='LIB:EcoGene'/> | Sequesters newly replicated hemimethylated oriC origins to prevent re-initiation; binds hemimethylated GATC sequences; SeqA foci required for chromosome segregation; binds and stimulates Topo IV<ref name='LIB:EcoGene'/> | ||
|- | |- | ||
!align=left | !align=left {{table_heading_style}} |Product Synonyms(s) | ||
|| | || | ||
regulatory protein for replication initiation<ref name='LIB:Riley_2006'/>, B0687<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SeqA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | regulatory protein for replication initiation<ref name='LIB:Riley_2006'/>, B0687<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SeqA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | ||
|- | |- | ||
!align=left | !align=left {{table_heading_style}} |Function from GO | ||
|| | || | ||
'''Molecular Function''' | |||
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI]) | |||
|- | |- | ||
!align=left | !align=left {{table_heading_style}} |Knock-Out Phenotype | ||
|| | |||
|- | |||
!align=left {{table_heading_style}} |Regulation/Expression | |||
|| | || | ||
transcription unit(s): [[:Category:Txn_unit:seqA-pgm|seqA-pgm]]<ref name='LIB:EcoCyc10.6'/> | transcription unit(s): [[:Category:Txn_unit:seqA-pgm|seqA-pgm]]<ref name='LIB:EcoCyc10.6'/> | ||
|- | |- | ||
!align=left | !align=left {{table_heading_style}} |Regulation/Activity | ||
|| | || | ||
|- | |||
!align=left {{table_heading_style}} |Quick Links | |||
|| | |||
[http://ecoliwiki.net/tools/display_dna.php?gene=seqA&loc=MG1655:712210..712755,W3110:713409..713954,DH10B:764802..765347,REL606:695082..695627 DNA display] [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=695082&end=695627&gene=seqA&aa=mktievddelysyiashtkhigesasdilrrmlkfsaasqpaapvtkevrvaspaiveakpvktikdkvramrelllsdeyaeqkravnrfmlllstlysldaqafaeateslhgrtrvyfaadeqtllkngnqtkpkhvpgtpywvitntntgrkcsmiehimqsmqfpaeliekvcgti Protein display] [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=seqA+AND+escherichia+coli Pubmed(seqA)] [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=seqA Textpresso(seqA)] | |||
|- class="tableEdit_footer" | |- class="tableEdit_footer" | ||
Revision as of 00:29, 22 January 2010
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
See Help:Quickview for help with entering information in the Quickview table.
| Standard Name |
seqA |
|---|---|
| Gene Synonym(s) |
ECK0675, b0687, JW0674[1] |
| Product Desc. |
SeqA, negative modulator of initiation of replication[2][3] Sequesters newly replicated hemimethylated oriC origins to prevent re-initiation; binds hemimethylated GATC sequences; SeqA foci required for chromosome segregation; binds and stimulates Topo IV[4] |
| Product Synonyms(s) |
regulatory protein for replication initiation[1], B0687[2][1], SeqA[2][1] |
| Function from GO |
Molecular Function
|
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links | |
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
SeqA is required for the membrane binding of hemimethylated oriC in vitro. SeqA may facilitate cII binding to phage lambda promoters, enhancing transcription. SeqA self-association function is in the N-terminal domain. DNA-binding activity is in C-terminal domain. SeqA expression is negatively modulated by HU. SeqA is a homotetramer. aphA(hobH) mutants overproduce SeqA.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.