seqA:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Standard Name |
seqA |
|---|---|
| Gene Synonym(s) |
ECK0675, b0687, JW0674[1], JW0674 |
| Product Desc. |
SeqA, negative modulator of initiation of replication[2][3] Sequesters newly replicated hemimethylated oriC origins to prevent re-initiation; binds hemimethylated GATC sequences; SeqA foci required for chromosome segregation; binds and stimulates Topo IV[4] |
| Product Synonyms(s) |
regulatory protein for replication initiation[1], B0687[2][1], SeqA[2][1] , ECK0675, JW0674, b0687 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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Notes
SeqA is required for the membrane binding of hemimethylated oriC in vitro. SeqA may facilitate cII binding to phage lambda promoters, enhancing transcription. SeqA self-association function is in the N-terminal domain. DNA-binding activity is in C-terminal domain. SeqA expression is negatively modulated by HU. SeqA is a homotetramer. aphA(hobH) mutants overproduce SeqA.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.