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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''amiC''  
''amiC''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK2813, b2817, JW5449, ygdN''<ref name='LIB:Riley_2006'/>
''ECK2813, b2817, JW5449, ygdN''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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N-acetylmuramyl-L-alanine amidase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
N-acetylmuramyl-L-alanine amidase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
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N-acetylmuramyl-L-alanine amidase, periplasmic; recruited to the septal ring by FtsN during cell division; overexpression causes lysis<ref name='LIB:EcoGene'/>
N-acetylmuramyl-L-alanine amidase, periplasmic; recruited to the septal ring by FtsN during cell division; overexpression causes lysis<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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N-acetylmuramoyl-L-alanine amidase<ref name='LIB:Riley_2006'/>, B2817<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YgdN<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AmiC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
N-acetylmuramoyl-L-alanine amidase<ref name='LIB:Riley_2006'/>, B2817<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YgdN<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AmiC<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Cellular Component'''
* GO:0042597 periplasmic space ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0009252 peptidoglycan biosynthetic process ([http://www.geneontology.org/GO.evidence.shtml IGI])
'''Molecular Function'''
* GO:0008745 N-acetylmuramoyl-L-alanine amidase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
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Septation defect<ref name='PMID:16855223'/>.  Increases the number of cells in chains
Septation defect<ref name='PMID:16855223'/>.  Increases the number of cells in chains
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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:amiC|amiC]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:amiC|amiC]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=amiC&loc=MG1655:2947032..2945779,W3110:2947666..2946413,REL606:2843629..2842376,DH10B:3040902..3039649 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3040902&end=3039649&gene=amiC&aa=mtdyasfakvsgqisrllvtqlrflllgrgmsgsntaisrrrllqgagamwllsvsqvslaavsqvvavrvwpassytrvtvesnrqlkykqfalsnpervvvdiedvnlnsvlkgmaaqiraddpfiksarvgqfdpqtvrmvfelkqnvkpqlfalapvagfkerlvmdlypanaqdmqdpllalledynkgdlekqvppaqsgpqpgkagrdrpivimldpghggedsgavgkyktrekdvvlqiarrlrsliekegnmkvymtrnedifiplqvrvakaqkqradlfvsihadaftsrqpsgssvfalstkgatstaakylaqtqnasdliggvsksgdryvdhtmfdmvqsltiadslkfgkavlnklgkinklhknqveqagfavlkapdipsilvetafisnveeerklktatfqqevaesilagikayfadgatlarrg Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=amiC+AND+escherichia+coli Pubmed(amiC)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=amiC Textpresso(amiC)]


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Revision as of 00:12, 22 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

amiC

Gene Synonym(s)

ECK2813, b2817, JW5449, ygdN[1]

Product Desc.

N-acetylmuramyl-L-alanine amidase[2][3]

N-acetylmuramyl-L-alanine amidase, periplasmic; recruited to the septal ring by FtsN during cell division; overexpression causes lysis[4]

Product Synonyms(s)

N-acetylmuramoyl-L-alanine amidase[1], B2817[2][1], YgdN[2][1], AmiC[2][1]

Function from GO

Cellular Component

Biological Process

Molecular Function

Knock-Out Phenotype

Septation defect[5]. Increases the number of cells in chains

Regulation/Expression

transcription unit(s): amiC[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(amiC)    Textpresso(amiC)

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See Help:Quickview for help with entering information in the Quickview table.

Notes

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Verified Tat substrate: AmiC has a predicted Tat-only (Class I) 31 aa signal peptide (Tullman-Ercek, 2007). N-terminal domain is septal targeting domain. Ize (2003) incorrectly report a predicted 33 aa signal peptide in the text, but correctly depict a predicted 31 aa signal peptide in Fig. 4A. Divisome, non-essential.[4]



References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Priyadarshini, R et al. (2006) Daughter cell separation by penicillin-binding proteins and peptidoglycan amidases in Escherichia coli. J. Bacteriol. 188 5345-55 PubMed
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