glmS:Quickview: Difference between revisions

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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''glmS''  
''glmS''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK3722, b3729, JW3707''<ref name='LIB:Riley_2006'/>
''ECK3722, b3729, JW3707''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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GlmS<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
GlmS<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Glucosamine-6-phosphate synthase; glucosamine--fructose-6-phosphate aminotransferase; C-terminal F6P-binding domain has isomerase activity<ref name='LIB:EcoGene'/>
Glucosamine-6-phosphate synthase; glucosamine--fructose-6-phosphate aminotransferase; C-terminal F6P-binding domain has isomerase activity<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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L-glutamine:D-fructose-6-phosphate aminotransferase<ref name='LIB:Riley_2006'/>, B3729<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GlmS<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
L-glutamine:D-fructose-6-phosphate aminotransferase<ref name='LIB:Riley_2006'/>, B3729<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, GlmS<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
* GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI])
'''Biological Process'''
* GO:0006048 UDP-N-acetylglucosamine biosynthetic process ([http://www.geneontology.org/GO.evidence.shtml IMP])
'''Cellular Component'''
* GO:0005829 cytosol ([http://www.geneontology.org/GO.evidence.shtml IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:glmUS|glmUS]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:glmUS|glmUS]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=glmS&loc=MG1655:3911691..3909862,W3110:3723013..3724842,REL606:3874034..3872205 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3874034&end=3872205&gene=glmS&aa=mcgivgaiaqrdvaeilleglrrleyrgydsaglavvdaeghmtrlrrlgkvqmlaqaaeehplhggtgiahtrwathgepsevnahphvsehivvvhngiienheplreelkargytfvsetdteviahlvnwelkqggtlreavlraipqlrgaygtvimdsrhpdtllaarsgsplviglgmgenfiasdqlallpvtrrfifleegdiaeitrrsvnifdktgaevkrqdiesnlqydagdkgiyrhymqkeiyeqpnaikntltgrishgqvdlselgpnadellskvehiqilacgtsynsgmvsrywfeslagipcdveiasefryrksavrrnslmitlsqsgetadtlaglrlskelgylgslaicnvpgsslvresdlalmtnagteigvastkafttqltvllmlvaklsrlkgldasiehdivhglqalpsrieqmlsqdkriealaedfsdkhhalflgrgdqypialegalklkeisyihaeayaagelkhgplalidadmpvivvapnnelleklksnieevrarggqlyvfadqdagfvssdnmhiiemphveeviapifytvplqllayhvalikgtdvdqprnlaksvtve Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=glmS+AND+escherichia+coli Pubmed(glmS)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=glmS Textpresso(glmS)]


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Revision as of 23:56, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

glmS

Gene Synonym(s)

ECK3722, b3729, JW3707[1]

Product Desc.

GlmS[2][3];

Component of L-glutamine:D-fructose-6-phosphate aminotransferase[2][3]

Glucosamine-6-phosphate synthase; glucosamine--fructose-6-phosphate aminotransferase; C-terminal F6P-binding domain has isomerase activity[4]

Product Synonyms(s)

L-glutamine:D-fructose-6-phosphate aminotransferase[1], B3729[2][1], GlmS[2][1]

Function from GO

Molecular Function

Biological Process

Cellular Component

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): glmUS[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(glmS)    Textpresso(glmS)

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See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


GlmS synthesis s negatively feedback regulated by glucosamine-6-phosphate, which probably causes YhbJ to cleave and inactivate the GlmZ sRNA; GlmZ upregulates glmS mRNA post-translationally (Kalamorz, 2007). THe GlmY sRNA also regulates glmS post-transcriptionally (Urban, 2007). GlmS can be inactivated by various halomethyl and methyl ketone derivatives, of which bromomethyl ketone derivative is most effective because of its high binding affinity.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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