glmS:Quickview

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References Suggestions

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Standard Name

glmS

Gene Synonym(s)

ECK3722, b3729, JW3707[1], JW3707

Product Desc.

GlmS[2][3];

Component of L-glutamine:D-fructose-6-phosphate aminotransferase[2][3]

Glucosamine-6-phosphate synthase; glucosamine--fructose-6-phosphate aminotransferase; C-terminal F6P-binding domain has isomerase activity[4]

Product Synonyms(s)

L-glutamine:D-fructose-6-phosphate aminotransferase[1], B3729[2][1], GlmS[2][1] , ECK3722, JW3707, b3729

Function from GO

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Knock-Out Phenotype
Regulation/Expression

transcription unit(s): glmUS[2]

Regulation/Activity
Quick Links

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Notes

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GlmS synthesis s negatively feedback regulated by glucosamine-6-phosphate, which probably causes YhbJ to cleave and inactivate the GlmZ sRNA; GlmZ upregulates glmS mRNA post-translationally (Kalamorz, 2007). THe GlmY sRNA also regulates glmS post-transcriptionally (Urban, 2007). GlmS can be inactivated by various halomethyl and methyl ketone derivatives, of which bromomethyl ketone derivative is most effective because of its high binding affinity.[4]



References

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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.