mrcB:Quickview: Difference between revisions

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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''mrcB''  
''mrcB''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK0148, b0149, JW0145, pbpF, ponB''<ref name='LIB:Riley_2006'/>
''ECK0148, b0149, JW0145, pbpF, ponB''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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MrcB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
MrcB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Murein polymerase, PBP1B; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1B; dimeric<ref name='LIB:EcoGene'/>
Murein polymerase, PBP1B; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1B; dimeric<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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fused glycosyl transferase<ref name='LIB:Riley_2006'/>, transpeptidase<ref name='LIB:Riley_2006'/>, B0149<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PonB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PbpF<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MrcB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PBP1B<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
fused glycosyl transferase<ref name='LIB:Riley_2006'/>, transpeptidase<ref name='LIB:Riley_2006'/>, B0149<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PonB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PbpF<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MrcB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PBP1B<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Cellular Component'''
* GO:0005624 membrane fraction ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0005739 mitochondrion ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Molecular Function'''
* GO:0008144 drug binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0008955 peptidoglycan glycosyltransferase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:mrcB|mrcB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:mrcB|mrcB]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=mrcB&loc=MG1655:164730..167264,W3110:164730..167264,DH10B:138834..141368,REL606:167581..170106 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=167581&end=170106&gene=mrcB&aa=magndrepigrkgkptrpvkqkvsrrryeddddyddyddyedeepmprkgkgkgkgrkprgkrgwlwlllklaivfavliaiygvyldqkirsridgkvwqlpaavygrmvnlepdmtisknemvklleatqyrqvskmtrpgeftvqansiemirrpfdfpdskegqvrarltfdgdhlativnmennrqfgffrldprlitmisspngeqrlfvprsgfpdllvdtllatedrhfyehdgislysigravlanltagrtvqgastltqqlvknlflssersywrkaneaymalimdaryskdrilelymnevylgqsgdneirgfplaslyyfgrpveelsldqqallvgmvkgasiynpwrnpklalerrnlvlrllqqqqiidqelydmlsarplgvqprggvispqpafmqlvrqelqaklgdkvkdlsgvkifttfdsvaqdaaekaavegipalkkqrklsdletaivvvdrfsgevramvggsepqfagynramqarrsigslakpatyltalsqpkiyrlntwiadapialrqpngqvwspqnddrrysesgrvmlvdaltrsmnvptvnlgmalglpavtetwiklgvpkdqlhpvpamllgalnltpievaqafqtiasggnraplsalrsviaedgkvlyqsfpqaeravpaqaayltlwtmqqvvqrgtgrqlgakypnlhlagktgttnnnvdtwfagidgstvtitwvgrdnnqptklygasgamsiyqrylanqtptplnlvppediadmgvdydgnfvcsggmrilpvwtsdpqslcqqsemqqqpsgnpfdqssqpqqqpqqqpaqqeqkdsdgvagwikdmfgsn Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=mrcB+AND+escherichia+coli Pubmed(mrcB)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=mrcB Textpresso(mrcB)]


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Revision as of 23:42, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

mrcB

Gene Synonym(s)

ECK0148, b0149, JW0145, pbpF, ponB[1]

Product Desc.

MrcB[2][3];

Component of penicillin-binding protein 1B[3]

Murein polymerase, PBP1B; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1B; dimeric[4]

Product Synonyms(s)

fused glycosyl transferase[1], transpeptidase[1], B0149[2][1], PonB[2][1], PbpF[2][1], MrcB[2][1], PBP1B[2][1]

Function from GO

Cellular Component

Molecular Function

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): mrcB[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(mrcB)    Textpresso(mrcB)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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MrcB is part of a complex with MltA and MipA. The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Full length MrcB is the alpha isoform. A second in vivo ATG start at codon 46 produces the 799 aa gamma isoform. Murein polymerase is an essential function satisfied by either MrcA or MrcB. Mutants have elevated OM vesiculation (McBroom, 2006). MrcB is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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