seqA:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Standard Name
!align=left |Standard Name
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''seqA''  
''seqA''  
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!align=left {{table_heading_style}} |Gene Synonym(s)
!align=left |Gene Synonym(s)
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''ECK0675, b0687, JW0674''<ref name='LIB:Riley_2006'/>
''ECK0675, b0687, JW0674''<ref name='LIB:Riley_2006'/>
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!align=left {{table_heading_style}} |Product Desc.
!align=left |Product Desc.
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SeqA, negative modulator of initiation of replication<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
SeqA, negative modulator of initiation of replication<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
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Sequesters newly replicated hemimethylated oriC origins to prevent re-initiation; binds hemimethylated GATC sequences; SeqA foci required for chromosome segregation; binds and stimulates Topo IV<ref name='LIB:EcoGene'/>
Sequesters newly replicated hemimethylated oriC origins to prevent re-initiation; binds hemimethylated GATC sequences; SeqA foci required for chromosome segregation; binds and stimulates Topo IV<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
!align=left |Product Synonyms(s)
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regulatory protein for replication initiation<ref name='LIB:Riley_2006'/>, B0687<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SeqA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
regulatory protein for replication initiation<ref name='LIB:Riley_2006'/>, B0687<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SeqA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:seqA-pgm|seqA-pgm]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:seqA-pgm|seqA-pgm]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left |Regulation/Activity
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Revision as of 00:39, 10 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

seqA

Gene Synonym(s)

ECK0675, b0687, JW0674[1]

Product Desc.

SeqA, negative modulator of initiation of replication[2][3]

Sequesters newly replicated hemimethylated oriC origins to prevent re-initiation; binds hemimethylated GATC sequences; SeqA foci required for chromosome segregation; binds and stimulates Topo IV[4]

Product Synonyms(s)

regulatory protein for replication initiation[1], B0687[2][1], SeqA[2][1]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): seqA-pgm[2]

Regulation/Activity


edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


SeqA is required for the membrane binding of hemimethylated oriC in vitro. SeqA may facilitate cII binding to phage lambda promoters, enhancing transcription. SeqA self-association function is in the N-terminal domain. DNA-binding activity is in C-terminal domain. SeqA expression is negatively modulated by HU. SeqA is a homotetramer. aphA(hobH) mutants overproduce SeqA.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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