msbA:Quickview: Difference between revisions

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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''msbA''  
''msbA''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK0905, b0914, JW0897''<ref name='LIB:Riley_2006'/>
''ECK0905, b0914, JW0897''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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ATP-binding transport protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
ATP-binding transport protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
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Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase<ref name='LIB:EcoGene'/>
Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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fused lipid transporter subunits of ABC superfamily: membrane component<ref name='LIB:Riley_2006'/>, ATP-binding component<ref name='LIB:Riley_2006'/>, B0914<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MsbA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
fused lipid transporter subunits of ABC superfamily: membrane component<ref name='LIB:Riley_2006'/>, ATP-binding component<ref name='LIB:Riley_2006'/>, B0914<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MsbA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
* GO:0005319 lipid transporter activity ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0005524 ATP binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0015437 lipopolysaccharide-transporting ATPase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0016887 ATPase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Cellular Component'''
* GO:0005624 membrane fraction ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0005739 mitochondrion ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0006869 lipid transport ([http://www.geneontology.org/GO.evidence.shtml IMP])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:ycaI|ycaI]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:ycaI|ycaI]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=msbA&loc=MG1655:965844..967592,W3110:967043..968791,DH10B:1019772..1021520,REL606:983713..985461 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=983713&end=985461&gene=msbA&aa=mhndkdlstwqtfrrlwptiapfkaglivagvalilnaasdtfmlsllkpllddgfgktdrsvlvwmplvviglmilrgitsyvssyciswvsgkvvmtmrrrlfghmmgmpvsffdkqstgtllsritydseqvassssgalitvvregasiiglfimmfyyswqlsiilivlapivsiairvvskrfrnisknmqntmgqvttsaeqmlkghkevlifggqevetkrfdkvsnrmrlqgmkmvsassisdpiiqliaslalafvlyaasfpsvmdsltagtitvvfssmialmrplksltnvnaqfqrgmaacqtlftildseqekdegkrvieratgdvefrnvtftypgrdvpalrninlkipagktvalvgrsgsgkstiaslitrfydidegeilmdghdlreytlaslrnqvalvsqnvhlfndtvanniayarteqysreqieeaarmayamdfinkmdngldtvigengvllsggqrqriaiarallrdspilildeatsaldteseraiqaaldelqknrtslviahrlstiekadeivvvedgvivergthndllehrgvyaqlhkmqfgq Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=msbA+AND+escherichia+coli Pubmed(msbA)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=msbA Textpresso(msbA)]


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Revision as of 23:42, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

msbA

Gene Synonym(s)

ECK0905, b0914, JW0897[1]

Product Desc.

ATP-binding transport protein[2][3]

Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase[4]

Product Synonyms(s)

fused lipid transporter subunits of ABC superfamily: membrane component[1], ATP-binding component[1], B0914[2][1], MsbA[2][1]

Function from GO

Molecular Function

Cellular Component

Biological Process

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ycaI[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(msbA)    Textpresso(msbA)

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See Help:Quickview for help with entering information in the Quickview table.

Notes

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MsbA PDB structures 1JSQ, 1PF4 and 1Z2R, and any conclusions derived from these structures, have been retracted due to a software data inversion error (Chang, 2006). A yhjD point mutation (R134C) allows the deletion of the otherwise essential msbA gene (Mamat, 2007). MsbA point mutations confering S18P or S50P suppress the lethal phenotype of a KDO null gutQ kdsD double mutant (Mamat, 2007).[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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